Signals in B 6 C 3 F 1 Mice
نویسندگان
چکیده
The purpose of this study using a total of 1170 B6C3F1 mice was to detect and evaluate possible carcinogenic effects in mice exposed to radio-frequency-radiation (RFR) from Global System for Mobile Communication (GSM) and Digital Personal Communications System (DCS) handsets as emitted by handsets operating in the center of the communication band, that is, at 902MHz (GSM) and 1747 MHz (DCS). Restrained mice were exposed for 2 h per day, 5 days per week over a period of 2 years to three different whole-body averaged specific absorption rate (SAR) levels of 0.4, 1.3, 4.0 mW/g bw (SAR), or were sham exposed. Regarding the organ-related tumor incidence, pairwise Fisher’s test did not show any significant increase in the incidence of any particular tumor type in the RF exposed groups as compared to the sham exposed group. Interestingly, while the incidences of hepatocellular carcinomas were similar in EMF and sham exposed groups, in both studies the incidences of liver adenomas inmales decreasedwith increasing dose levels; the incidences in the high dose groups were statistically significantly different from those in the sham exposed groups. Comparison to published tumor rates in untreated mice revealed that the observed tumor rates were within the range of historical control data. In conclusion, the present study produced no evidence that the exposure of male and female B6C3F1mice towireless GSM and DCS radio frequency signals at a whole body absorption rate of up to 4.0 W/kg resulted in any adverse health effect or had any cumulative influence on the incidence or severity of neoplastic and non-neoplastic background lesions, and thus the study did not provide any evidence of RF possessing a carcinogenic potential. Bioelectromagnetics 28:173–187, 2007. 2006 Wiley-Liss, Inc.
منابع مشابه
Enhancement of NMRI Mouse Embryo Development In vitro
Most of the systematic studies used in the development of human embryo culture media have been done first on mouse embryos. The general use of NMRI outbred mice is a model for toxicology, teratology and pharmacology. NMRI mouse embryo exhibit the two-cell block in vitro. The objective of this study was to evaluate and compare the effects of four kinds of culture media on the development of zygo...
متن کاملEffects of Daily Intake of Plant and Animal Oils on the Incidence of Depression in Adult Mice
Background: Depression is a complicated disturbance affected by a collection of biological and environmental factors. The first aim of psychiatric studies is to recognize biological markers that could be utilized to predict improvement and increase reactions to antidepressant treatments. Diet affects different aspects of health, including depression. The aim of study was to determine antidepres...
متن کاملThe Effect of Glycoprotein B DNA Immuniation on HSV-l Lethal Infection of BALB/c Mice
Background and Aims: Glycoprotein B (gB) is among the most important immunogenic proteins of HSV-1 that is now being used as recombinant vaccine to induce protectively against the virus. It is believed that gB is responsible for induction of neutralizing antibody and up to 90% of CTL (Cytotoxic T Cell) activity against HSV-1 in some haplotypes. Methods: In the present study the antibody titer ...
متن کاملAnti-inflammatory Effect of Ethanolic Extract of Euphorbia myrsinites in Lipopolysaccharide-induced Septic Shock in Mice
Background and purpose: Many herbs including Euphorbia have immunomodulatory properties. The aim of this study was to evaluate the immunomodulatory effects of the ethanolic extract of E.myrsinites. Materials and methods: In this experimental study, 40 Swiss albino male mice were randomly divided into 4 groups. Group A included healthy mice, group B was induced by lipopolysaccharide (LPS), grou...
متن کاملبررسی اثر عصاره الکلی گیاه ترشک (Rumex) بر روی لیشمانیوز پوستی ناشی از لیشمانیا ماژور (Leishmania major) در موش های Balb/C
Background:Cutaneous leishmaniasis is an endemic disease in many countries, including Iran. Pentavalent antimony compounds used to treat this disease is associated with adverse effects for patients. The aims of this study were to evaluate the effectiveness of the alcoholic extract of Rumex on experimental lesion of Leishmania major in Bulb/C mice. Methods: In this study, thirty mice were divide...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007